Pietro Gambadauro a,b,*, Ramesan Navaratnarajah c,d
a. Karolinska Institutet, Stockholm, Sweden; b. Res Medica Sweden, Uppsala, Sweden; c. Bart’s Health NHS Trust, London, UK; d. Katherine Twining Network, Queen Mary University of London, London, UK.
Reprod BioMed Online 2015;30:137-143 , DOI: 10.1016/j.rbmo.2014.10.013
This article is avaliable in its final version for free! JUST CLICK HERE!!!
Anyone who clicks on the link until March 23, 2015, will be taken to the final version of our article on ScienceDirect for free. No sign up or registration is needed – just click and read!
- Recent reports of IVF randomized trials rarely describe embryo transfer methods.
- Most commonly reported details refer to transfer catheters or ultrasound guidance.
- ET methods reporting is not commoner in more prestigious studies.
- RCTs in higher impact factor journals (IF?3) are less likely to describe ET methods.
- Methods underreporting undermines reproducibility and suitability for meta-analysis.
The reporting of embryo transfer methods in IVF research was assessed through a cross-sectional analysis of randomized controlled trials (RCTs) published between 2010 and 2011. A systematic search identified 325 abstracts; 122 RCTs were included in the study. Embryo transfer methods were described in 42 out of 122 articles (34%). Catheters (32/42 [76%]) or ultrasound guidance (31/42 [74%]) were most frequently mentioned. Performer ‘blinding’ (12%) or technique standardization (7%) were seldom re- ported. The description of embryo transfer methods was significantly more common in trials published by journals with lower impact factor (less than 3, 39.6%; 3 or greater, 21.5%; P = 0.037). Embryo transfer methods were reported more often in trials with preg- nancy as the main end-point (33% versus 16%) or with positive outcomes (37.8% versus 25.0%), albeit not significantly. Multivariate logistic regression confirmed that RCTs published in higher impact factor journals are less likely to describe embryo transfer methods (OR 0.371; 95% CI 0.143 to 0.964). Registered trials, trials conducted in an academic setting, multi-centric studies or full-length ar- ticles were not positively associated with embryo transfer methods reporting rate. Recent reports of randomized IVF trials rarely describe embryo transfer methods. The under-reporting of research methods might compromise reproducibility and suitability for meta-analysis.